Annual Meeting 2007
HAI 2007
HAI 2007
Date: 19th,
20th, 21st October 2007
Venue: Clarion Hotel, Sligo
President's
Letter
It is a pleasure to
welcome everyone to the Annual Scientific Meeting of
the Haematology Association of Ireland at this excellent
venue, the Clarion Hotel in Sligo. We are building on
the continuing success of previous meetings by attracting
more clinical haematologists, healthcare scientists,
nurses and allied professionals across haematological
practice.
This year we will have
the privilege of hearing talks from a number of distinguished
international speakers. Trevor Baglin, fresh from delivering
the BSH Medal Lecture at Bournemouth will give a talk
entitled -Venous thrombosis: patient-focussed or disease
focussed-care?- We welcome two visitors from the United
States: John Cunningham from Chicago will speak about
sickle cell disease and Alan List from Tampa about myelodysplasia.
John Gribben from Bart's has chosen the topic
of lymphoma. From closer to home, Emer Lawlor will cover
Haemovigilance and the EU Blood Directive and Ken Mills,
recently appointed to the new Chair of Experimental
Haematology at QUB will speak about the use of microarrays
in the diagnosis of leukaemia. We eagerly anticipate
hearing about the latest developments in these interesting
topics.
As usual Posters and
Free Communications will have a prominent place on the
programme, providing an excellent opportunity to elicit
views and comments from colleagues.
On a personal note,
at the end of my term as President of the Association,
I would like to thank Corrina McMahon our Secretary/Treasurer
and Eibhlin Conneally our Scientific Secretary for their
heroic efforts in organising the last three Annual Scientific
Meetings, and the Committee Members who contributed
through attendance at our increasingly efficient multicentre
video link-ups. It has been a pleasure to serve the
Association at this important time in its development.
At last year's
AGM in Cork, members endorsed unanimously the recommendation
of the Committee to seek Charitable Status as a Limited
Company and voted formally on this in January of this
year, again unanimously. The legal transactions are
underway at present and we expect the process to be
complete before the end of the year. Our new status
underlines the sustained growth of the Association,
which had its foundations in the Blood Club in the 1970's.
One of the most memorable
events of my tenure was to attend the Meeting of the
National Presidents at the European Hematology Association
in Vienna in June. It is vitally important that as HAI
continues to grow we should seek opportunities to play
a greater role in EHA, an increasingly influential organisation.
I wish the HAI continued
success in the future.
Terry Lappin
Terry Lappin
President 2005-2007
FRIDAY 19th
OCTOBER 2007
10.45 - 11.30
Registration and Coffee
Registration:
Conference Lobby
Coffee:
Pre Conference Area
11.30 - 13.00
MAIN SESSION 1 (Free paper session 1)
Venue:
Pegasus 1
Chairs:
Prof M. O'Dwyer, Dr A. Hodgson
11.30 - 11.40 O1 Red cell microparticles
in patients with sickle cell disease.
Andrea Piccin1, Elva Eakins1, Ciaran Murphy1, Ruth Larragy1,
Corrina McMahon2, Owen P Smith2 & William
G. Murphy1Irish Blood Transfusion Service, 2Our Lady's
Hospital for Sick Children.
11.40 - 11.50
O2 PHF23: an Erythropoietin-responsive chromatin
effector protein.
Vivien M. Hodges1*, Susan Rainey1, Victoria Smyth1,
Ken I. Mills1, Terence R.J. Lappin1 and A. Peter Maxwell2.
1Centre for Cancer Research and Cell Biology, Queen's
University Belfast; 2Regional Nephrology Unit, Belfast
City Hospital, Belfast, Northern Ireland.
11.50 - 12.00 O3 Functional insights into
the role of HOXA6 in Haematopoiesis.
Glenda J. McGonigle, Damian P.J. Finnegan, Mary Frances
McMullin, Terence R.J. Lappin, and Alexander Thompson.
Haematology Research Group, CCRCB, Queen-s University
Belfast, BT9 7AB.
12.00 -12.10
O4 Bronchoalveolar lavage in the diagnosis of
pulmonary disease / infections in children with haematological
malignancies.
1U. Rao, 1A. O'Marcaigh, 1A O'Meara, 1F
Breatnach, 1A Piccin, 1A Gahan, 2M McDermott, 3N O'Sullivan,
4J Russell, 1O P. Smith. 1C McMahon Departments of 1Haematology
& Oncology, 2Histopathology, 3Microbiology and 4Otolaryngology,
Our Lady's Children's Hospital, Crumlin,
Dublin 12.
12.20 - 12.30
O5 Characteristics & outcome of newly diagnosed
elderly AML patients treated at University College Hospital,
Galway in a 10-year period: a retrospective analysis.
H Osman, M O'Dwyer, University Hospital
Galway.
12.30 -12.40
O6 Fine-mapping the protein S binding site on the activated
protein C GLA domain
S. Harmon, J. Johnson, R. Preston, M. Cunningham, B.
White, O. Smith and J O'Donnell. Haemostasis Research
Group, Institute of Molecular Medicine, Trinity College
Dublin.
12.40 - 12.50
O7 Randomised controlled trial of supervised patient
self-testing of warfarin therapy using an internet based
expert system - Interim Results
F Ryan*, S Byrne*, S O Shea†., *Pharmaceutical
Care Research Group, School of Pharmacy, University
College Cork, †Department of Haematology, Cork
University Hospital.
12.50 - 13.00
O8 High Through-Put, Individual Donor Nucleic
Acid Testing (NAT) for HCV, HIV-1 and HBV using the
Procleix Tigris System.
O'Riordan JM, Murphy J, Williams P, Donnellan
J. IBTS, National Blood Centre, James's St, Dublin
8
13.00 - 14.00
LUNCH
Lunch Venue:
Sinergie Restaurant
Poster Viewing:
Pegasus 2
14.00 - 16.00
MAIN SESSION II
Venue:
Pegasus 1
Chairs:
Dr J. O'Donnell, Dr P. Browne
14.00 - 14.40
Haemovigilance 2000 -2007/ EU Directive: Where to from
here?
Dr Emer Lawlor, IBTS, National Blood Centre, James-s
St, Dublin 8
14.40 - 15.20
Gene expression driven diagnosis and prognosis in AML
and MDS.
Professor Ken Mills, Queens University. Belfast
15.20 - 16.00
Venous thrombosis: patient focussed or disease focussed
care?
Professor Trevor Baglin, Addenbrooks Hospital, Cambridge
16.00-16.30
COFFEE AND POSTER VIEWING
Venue:
Pre Conference area
16.30 - 17.30
MAIN SESSION III:
State of the Art
Venue:
Pegasus 1
Chair:
Dr. Corrina Mc Mahon, Our Lady's Children's
Hospital, Crumlin, Dublin
Sickle cell
disease; old problems and new opportunities.
Prof John Cunningham, Chief Haematology/Oncology in
Pediatrics, University of Chicago, Chicago.
17.45 - 18.30
HAI ANNUAL GENERAL MEETING
Venue:
Turcana
18.30 - 20.00
POSTER VIEWING (with interview of presenters)
Canapes and Wine sponsored by Bristol-Myers
Squibb
DINNER sponsored by AMGEN
Venue:
Pegasus 1
SATURDAY
20TH OCTOBER 2007
REGISTRATION
Venue:
Conference Lobby
09.00 - 10.30
MAIN SESSION IV (Free paper session 2)
Venue:
Pegasus 1
Chairs:
Dr P O Gorman, Dr M Cahill
09.00 - 09.10
O9 Pyrrolo-1,5-Benzoxazepine (PBOX)-15, a novel
tubulin depolymerization agent, induces apoptosis of
multiple myeloma cells in vitro
EN Maginn1, AM McElligott1, G Campiani2, DC Williams3,
DM Zisterer3, PV Browne1, MP Lawler1 1Department of
Haematology and Institute of Molecular Medicine, Trinity
Centre, St.James's Hospital, Dublin 8.
2Dipartimento Farmaco Chimico Technologico,
Universita'Degli Studi di Siena, Siena, Italy.
3Department of Biochemistry, Trinity
College, Dublin 2
09.10 - 09.20
O10 Use of Bortezomib In Northern Ireland - Combination
with Dexamethasone is Routinely Used to Improve Response
Rate.
Morris T.C.M.1, Drake
M.1, Kettle P.1, Hamilton J.2, Burnside P.3, Kyle A.3,
Boyd K.4, El-Agnaf M.5. 1Haematology Department, Belfast
City Hospital, 2Haematology Department, Altnagelvin
Hospital, 3Haematology Department, Antrim Area Hospital,
4Haematology Department, Craigavon Area Hospital,
5Haematology Department, Ulster Hospital. Northern
Ireland.
09.20 - 09.30
O11 Primary Plasma Cell Leukaemia And Autologous
Stem Cell Transplantation
Drake M. B.1, Iacobelli, S.2, Van Biezen A.2, Apperley
J. F.3, Niederwieser D.4, Bjorkstrand B.5, Gharton G.5,
Morris C1. 1Belfast City Hospital, Northern Ireland,
United Kingdom. 2Leiden University Medical Centre, Leiden,
The Netherlands. 3Hammersmith Hospital, London, United
Kingdom. 4University of Leipzig, Germany. 5Karolinska
Institute, Huddinge, Sweden.
09.30 - 09.40
O12 Mutation analysis of the BCR-ABL kinase domain
in Chronic Myeloid Leukaemia patients with resistance
or intolerance to the Tyrosine Kinase inhibitor, Imatinib
Mesylate
L O'Connor, S Langabeer, S McCann, E Conneally,
Department of Haematology, Trinity College Dublin &
St James Hospital, Dublin 8
09.50 - 10.00
O13 Activity of Dasatinib in Patients with Chronic Myeloid
Leukaemia who are Resistant or Intolerant to Imatinib
Mesylate.
Breen KA, Carroll P, Deegan P, Langabeer S, Haslam K,
Enright C, O'Connor F, O'Connor L, Conneally
E. Department of Haematology, St James Hospital &
Trinity College Dublin.
10.00 - 10.10
O14 F9 gene analysis in Irish patients with
Haemophilia B - identification of two novel causative
mutations and significant increased population prevalence
due to previously unreported founder effect.
R. Gilmore, H. Egan; C. Keenan; J. Smith; E. O'Shea,
B. Nolan; B. White; J. O-Donnell; PV Jenkins. National
Centre for Hereditary Coagulation Disorders, St. James's
Hospital, James Street, Dublin.
10.10 - 10.20
O15 Marked variation in the clearance
of Von Willebrand factor antigen and activity following
DDAVP administration - diagnostic utility and clinical
therapeutic implications.
J. Shrosbree; R. Gilmore; A. O'Sullivan; J. Smith,
V. Jenkins; B. Nolan; B. White; J. O-Donnell; National
Centre for Hereditary Coagulation Disorders, St. James
Hospital, Dublin.
10.20 - 10.30
O16 Radiotherapy and chemotherapy induce procoagulant
effects by modulating the ability of endothelial cells
to regulate the protein C pathway.
M. Cunningham, S.K. Brady, R. Preston, B. White, D.
Hollywood, J O'Donnell. Haemostasis Research Group,
and Academic Oncology Dept, IMM, Trinity College Dublin.
10.30 - 11.00
Coffee/poster viewing
11.00- 12.00
MAIN SESSION V
Venue:
Pegasus 1
Chair:
Dr B. Hennessy, Dr E. Vandenberghe
11.00 - 11.10
O17 Zevalin Radioimmunotherapy for patients with
indolent B-Cell Non Hodgkin's lymphoma (NHL):
From clinical trial to clinical practice.
P Evans, S Mc Guckin, R McDermott, G O'Reilly,
A Fortune, E Conneally, P Browne, E Vandenberghe. St.James's
Hospital, Dublin.
11.10 - 11.20
O18 Outcome of sibling reduced-intensity conditioning
allogeneic stem cell transplantations in low-grade B
cell lymphoproliferative disorders. A single center
experience.
R. Desmond, M. David, E. Conneally, P. Browne, M. Ni
Chonghaile, S. McCann, S O Brian E. Vandenberghe. Department
of Haematology, St.James's Hospital, Dublin.
11.20 -12.45
Plenary session
11.20 - 12.00
How do we decide the right treatment for low grade lymphomas?
Professor John Gribben, St Bartholomew's and the
London Hospital, London.
12.00 -
12.45 LIAM O' CONNELL MEMORIAL LECTURE
Chair:
Professor Terry Lappin, Queens's University Belfast
Venue:
Pegasus 1
The Development
of Lenalidomide in MDS
Professor Alan List. Division Chief Malignant Hematology.
H Lee Moffitt Cancer center and Research Institute,
Tampa, Florida
13.00
- 14.00 LUNCH
Venue:
Sinergie Restaurant
14.00 - 15.20
MAIN SESSION VII
Venue:
Pegasus 1
Chair:
Dr P. Thornton, Dr C. Morris
14.00 - 14.40
Targeted Therapy for PNH
Professor Peter Hillmen, Leeds Teaching Hospital NHS
Trust, Leeds.
14.40 - 14.50
O19 IGHV3-48 and IGHV3-53 gene rearrangements represent
unique subgroups in CLL and are associated with biased
lambda light chain restriction, homogenous LCDR3 sequences
and poor prognosis
MA Catherwood,1,3 L Galligan,1 D Gonzalez,2 TCM Morris,1
H D Alexander. 1,31Department of Haematology, Level
C, Belfast City Hospital Trust, Belfast, Northern Ireland;
2 Department of Haemato-Oncology, BLB, Institute of
Cancer Research, Surrey, UK. 3School of Biomedical Sciences,
University of Ulster, Coleraine, Northern Ireland.
14.50 - 15.00
O20 Membrane CD26 (dipedtidyl
peptidase IV) expression in B-CLL: a predictor of responsiveness
to 2--Deoxycoformycin?
L Galligana*, M A. Catherwooda,b, T.C.M. Morrisa,
H. D Alexandera,b.a Haemato-Oncology, Belfast HSC Trust,
Level C, Belfast City Hospital, Northern Ireland, UKb
School of Biomedical Sciences, University of Ulster,
Coleraine, Northern Ireland, UK
15.00 - 15.10
O21 Investigating promoter methylation of Wnt signalling
antagonists in CLL
A Perry2, AM Braiotta2, A Hayat1,2, A McElligott2, A
Dickenson3, M A Catherwood4, L Galligan4, E Vandenberghe1,
M Lawler1,2.
1Department of Haematology and 2Academic Unit of Clinical
and Molecular Oncology, St. James's Hospital and
Trinity College Dublin. 3Department of Genetics, University
of Newcastle upon Tyne UK. 4Department of Haematology,
Level C, Belfast City Hospital Trust, Belfast, Northern
Ireland
15.20 - 15.45
COFFEE/POSTER
15.45- 16.30
MAIN SESSION VIII
Chair:
Dr Gerard Crotty,
Haematology morphology quiz:
Dr Wendy Erber, Addenbrooks Hospital, Cambridge.
20.00 till late
BANQUET DINNER followed by Prize Presentation and Band
Venue:
Pegasus 1&2
Sponsors:
Dinner - Ortho Biotech
Prizes - HAI
Technopharm
Novartis
SUNDAY 21st
OCTOBER 2007
10.00 - 13.00
SESSION IX: Education Session for MRCPath Trainees
10.00 - 13.00 SESSION
X: Clinical Research Subcommittee and Scientific Subcommittee
for discussion of protocols (Open to all HAI members).
Venue:
If you would like an item to be added to the agenda
for the Clinical Research and Scientific Subcommittee
Meeting please e-mail them to: econneally@stjames.ie
Nurses Programme
Friday
19th OCTOber 2007
09.30 - 10.30
REGISTRATION and Coffee
Registration: Conference Lobby
Venue:
Pre Conference Area
10.30 - 14.00
SESSION 1
Venue:
Turcana
Chair:
Mary Kelly
10.30 - 11.00
BMT focus
Susan Piggott, BMT Co-ordinator, Belfast City
Hospital
11.00 - 11.30
Low grade NHL
Ger Walpole, CNS Haematology, Sligo General Hospital
11.30 - 12.00
New Therapies in Haematology
Liz O'Connell, ANP Candidate in Haematology,
AMNCH, Tallaght
12.00 - 12.30
DVD
Susan Piggott, BMT Co-ordinator, Belfast City Hospital
12.30 - 13.00
QUIZ
13.00 - 14.00
LUNCH AND POSTER VIEWING
Lunch Venue:
Sinergie Restaurant
Poster Viewing:
Pegasus 2
14.00 -1600
SESSION 11
Venue:
Turcana
Chair:
Caroline McCaughey
14.00 - 14.30
QUIZ results
14.30 - 15.00 Role
of ANP in Haematology and a Case Study
Mary Kelly, ANP Candidate, Mid-Leinster Region
15.00 - 15.15
A case study - Acute Splenic Sequestration in
Sickle Cell Disease
Rosena Geoghegan, ANP Candidate in Haemoglobinopathy
15.15 - 1600
“To grieve or not to grieve”
Yvonne O'Meara, Senior Social Worker, Mater Misericordiae,
Dublin
16.00 - 16.30
COFFEE
16.30 - 17.30 SESSION
111
State Of The Art
Sickle cell
disease; old problems and new opportunities.
Prof John Cunningham, Chief Haematology/Oncology in
Pediatrics, University of Chicago, Chicago.
Venue:
Pegasus 1
Chair:
Dr. Corrina Mc Mahon, Our Lady's Children's
Hospital, Crumlin
17.45 - 18.30
HAI ANNUAL GENERAL MEETING
Venue:
Turcana
18.30 - 20.00
POSTER VIEWING (with interview of presenters)
Canapes and Wine sponsored by Bristol-Myers
Squibb
2030
DINNER sponsored by AMGEN
Venue:
Pegasus 1
Nurses Programme
SATURDAY
20th OCTOber 2007
09.30- 10.00
REGISTRATION
Registration: Conference Lobby
Coffee:
Preconference area
10.00 - 12.00
SESSION 111
Venue:
Turcana
Chair:
Lorna Storey
10.00 - 10.45 Complimentary
and Alternative Medicine
Patricia Fox, Nurse Lecturer, UCD, Dublin
10.45 - 11.30
Paediatric BMT
Dr Aengus O Marcaigh, Consultant Haematologist, Our
Lady's Children's Hospital, Crumlin,
Dublin
11.30 - 12.00
Rehabilitation Issues in Haematology
Sarah Taggart, Senior Physiotherapist,
Belfast City Hospital
12.00 - 12.45
SESSION IV Liam O'Connell Memorial Lecture
Chair:
Professor Terry Lappin, Queens's University Belfast
Venue:
Pegasus 1
The Development
of Lenalidomide in MDS
Professor Alan List. Division Chief Malignant Hematology.
H Lee Moffitt Cancer center and Research Institute,
Tampa, Florida
13.00 - 14.00 LUNCH
Venue: Sinergie Restaurant
14.00 - 16.00
SESSION V
Venue: Pegasus 1
14.00 - 14.40
Targeted Therapy for PNH (main session)
Professor Peter Hillmen, Leeds teaching Hospital NHS
trust, Leeds.
Chair: Susan Piggott
Venue: Turcana
14.40 - 15.20
Vicarious Traumatisation in Cancer Nursing
Helen Sinclair, Nurse Lecturer, QUB, Belfast
15.20 - 15.35
Highlights from the medical sessions
Dr Mary Cahill, Consultant Haematologist, Cork
15.35 - 16.00
Haemochromatosis
Frances Neville, CNS in Haematology, Tullamore
16.00 - 16.30
HAI NURSES GROUP AGM
ALL MEMBERS PLEASE ATTEND
20.00 till late
BANQUET DINNER followed by Prize Presentation and Band
Venue:
Pegasus 1/2
Sponsors:
Dinner - Ortho Biotech
Prizes - HAI
Technopharm
Novartis
Cephalon
Thanks to our Sponsors:
- AMGEN
- NOVARTIS
- ORTHOBIOTECH
- MERCK SHARP & DOHME
- SCHERING AG
- TECHNOPHARM
- NAPP LABORATORIES
- GILEAD SCIENCES LTD
- SHIRE PHARMACEUTICALS IRL
- BRISTOL MYERS SQUIBB
- LEO PHARMA
- PHARMION
- BAXTER
- ROCHE PHARMACEUTICALS
- PFIZER
- OCTAPHARMA
- GENZYME
- ZENEUS
- BIOENVISION
- CELGENE
- PHARMACIA
- BIOFACT
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